They found that IL-3 is a powerful and irreversible inhibitor of TNF-induced bone resorption, even in the presence of other proinflammatory cytokines, such as IL-1α, transforming growth factor ...

In the adult skeleton, bone is in constant flux between resorption of old or damaged bone by osteoclasts and deposition of new bone by osteoblasts. The net balance between resorption and ...

In bone resorption, osteoclasts attach to the bone ... be pertinent to our understanding of the functions of cathepsin K inhibitors, which are currently being developed as drugs to treat metabolic ...