Expression plasmids of human (h) CTSD wildtype (wt), the disease-associated ... group results in an enzymatically inactive CTSD that still showed normal maturation and lysosomal localization. Cell ...

To identify proteolysis pathways and pro-inflammatory cytokine expression involved ... quantitative real-time PCR for Cathepsin L, B, S, H, D, MMP-9 and Interleukin (IL)-1 and IL-6 from mRNA isolated ...

Methods: Northern analysis was used to measure mRNA levels of cathepsins B ... of cathepsin K mRNA expression was seen in the knee joints of transgenic Del1 mice at the onset of cartilage degeneration ...