【导读】S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。2025年1月20日， 深圳湾实验室尹成骞教授团队在期刊 ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively ...

These novel compounds induce a non-apoptotic, iron-dependent oxidative form of cell death that we refer to as ferroptosis. We have found that this form of cell death is distinct from apoptosis and ...

This may hint at what lies ahead as we navigate the (mostly erroneous) tendency to identify every cell death process in drug hepatotoxicity and other liver diseases as ferroptosis. DILI is broadly ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

Columbia researchers have found that a rare type of lipid is a key driver of ferroptosis, a form of cell death discovered by ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

We investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the survival of starved cells and promotes cell competition, and ferroptosis that ...

Peripheral T-cell lymphoma (PTCL) is an aggressive tumor derived from mature T cells and natural killer cells with an extremely poor prognosis. Ferroptosis is a mechanism of cell death that is ...