Immunogenicity is critical to the success of allogeneic cell ... markers. The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that ...

Histologic assessment of a liver biopsy specimen remains the gold standard for quantifying fibrosis, with increasing interest in the use of noninvasive markers to allow more frequent sampling and ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

He was actually observing two distinct cell types: Kupffer cells (liver macrophages) and hepatic stellate cells (which ... Only by integrating markers of cellular morphology and physiological ...

Methods: The research used bioinformatics analysis and immunohistochemistry staining on fibrotic liver tissues from human and mouse models to assess AURKA expression. The cellular localization of ...

bham.ac.uk Introduction CD248 (endosialin) is a stromal cell marker expressed ... susceptibility to liver fibrosis via an effect on PDGF signalling, making it an attractive clinical target for the ...

Additionally, QZRG granules suppressed the proliferation of activated hepatic stellate cells. Conclusion: Our findings suggest that QZRG granules may exert anti-fibrotic effects by downregulating ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

Expression of the receptor RAGE in biliary epithelial cells (BECs) is essential for mounting a ductular reaction (DR) in response to chronic liver injury and promoting liver fibrosis via ...