Following liver injury, hepatic stellate cells undergo "activation" which connotes ... Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

HSCs are central to the development of liver fibrosis in NAFLD ... Regulation in the Fibrogenic Activation of Hepatic ...

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

Liver fibrosis is a late-stage consequence of ... to its active form (TGF-β), it promotes fibrosis by activating hepatic stellate cells (HSCs). These cells transform into myofibroblasts and ...