Following liver injury, hepatic stellate cells undergo "activation" which connotes ... Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.

HSCs are central to the development of liver fibrosis in NAFLD ... Regulation in the Fibrogenic Activation of Hepatic ...

Liver fibrosis is a late-stage consequence of ... to its active form (TGF-β), it promotes fibrosis by activating hepatic stellate cells (HSCs). These cells transform into myofibroblasts and ...

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific ...

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. A perfusion-independent method to isolate ultrapure liver ...

Fatty liver disease, or hepatic ... cells. Commonly associated with obesity, type 2 diabetes, and excessive alcohol consumption, it can lead to serious complications like inflammation, fibrosis ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...