Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

May 17, 2024 — A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD ...

Dublin, Jan. 15, 2025 (GLOBE NEWSWIRE) -- The "Prion Disease Market Assessment: Epidemiology, Treatment Landscape, Unmet Needs, Emerging Therapies, and Value & Access" report has been added to ...

These observations suggest that a diagnostic test for prion infections based on CSF or other non-brain tissues or excretia may be possible. Further studies will be required to demonstrate the ...