Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

They report in Cell this week that the system involves a ubiquitin-protein ligase that specifically targets four distinct mutant nuclear proteins for destruction by the proteasome. Protein quality ...

Their compounds activate 20S proteasomes, which can identify and degrade disordered proteins without the need for ubiquitin ...