Ubiquitin and the Biology of the Cell ... This irreversible process has evolved into a central regulator of many different signaling pathways. The book is organized into two discrete sections.

Nevertheless, the group has succeeded in visualizing such an interaction between the ubiquitin ligase HACE1 and its primary target protein, the signaling mediator RAC1. The researchers used a ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

This complex balances adhesion and guidance signaling to regulate neuronal migration timing and direction. This “push” signal is balanced by a “pull” signal, driven by the ubiquitin ligase ...

One major focus of Dr. Diehl’s research concerns the mechanisms whereby growth-signaling pathways regulate the cyclin D/CDK4/6 kinases and from this, the identification of therapeutic vulnerabilities.