As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Methods: The research used bioinformatics analysis and immunohistochemistry staining on fibrotic liver tissues from human and mouse models to assess AURKA expression. The cellular localization of ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

As a metabolic center, the liver prevents inappropriate immune responses to abundant ... DC were then isolated via CD11c positive selection (Miltenyi, 130-125-835). Naïve OT-I T cells were isolated ...

Expression of the receptor RAGE in biliary epithelial cells (BECs) is essential for mounting a ductular reaction (DR) in response to chronic liver injury and promoting liver fibrosis via ...

Background and aims: Thrombospondin 1 (TSP-1) is an important activator of latent transforming growth factor β (TGF-β) but little is known of the expression patterns and functions of TSP-1 in liver ...

Institute of Biology, University of Szczecin, Szczecin, Poland Department of Human Immunology, Institute of Medical Sciences, University of Rzeszow, Rzeszow, Poland Swiss Institute of Allergy and ...

14 Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA The field of pancreatic stellate cell (PSC ...

The following is a summary of “Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression,” published in the January 2025 issue of ...

Purity and Reproducibility: Advanced technology ensures the isolation of highly pure vesicles, free from contaminants, with consistent results across different samples. Versatility: Suitable for a ...