As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...
In the healthy liver, most macrophages are classified as Kupffer cells (KCs). However, upon liver injury, as seen, for example, in obesity, another subset of macrophages called lipid-associated ...
Canada Excellence Research Chair in Immunophysiology and Immunotherapy Paul Kubes reflects on progress in research, building a team, and his vision for the future of immunology after his first year at ...