Following liver injury, hepatic stellate cells undergo "activation" which connotes ... Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.

RNA interference and AURKA antagonism were used to examine the effects of AURKA on liver fibrosis, while RNA-sequencing, qRT-PCR, and western blotting were employed to elucidate the potential ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

1 Division of Liver Diseases ... to elucidate pathways of human hepatic fibrosis. We established and characterised two human HSC cell lines termed LX-1 and LX-2, and compared their features with those ...

HSCs are central to the development of liver fibrosis in NAFLD ... Regulation in the Fibrogenic Activation of Hepatic ...

Qizhu-Ruogan-Granules ameliorates CCl 4-induced liver fibrosis. • Continuous activation of hepatic stellate cells is the driving force behind the progression of liver fibrosis. • Activation of hepatic ...

Liver fibrosis is a late-stage consequence of ... to its active form (TGF-β), it promotes fibrosis by activating hepatic stellate cells (HSCs). These cells transform into myofibroblasts and ...

Activated hepatic stellate cell (aHSC) is mainly responsible for deposition of extracellular collagen matrix that causes liver fibrosis. Although several siRNAs adequately inhibited HSC activation in ...

Pirfenidone blocks many of the profibrogenic activities of activated hepatic stellate cells. Since this drug has already been approved for treatment in patients, it appears to be ready for a clinical ...

The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...