Ubiquitin-dependent protein degradation is a crucial cellular process that regulates protein turnover and maintains cellular homeostasis. This mechanism involves the tagging of proteins with ...

Additionally, the regulation of the MAPK signaling pathways by large HERC ubiquitin ligases has been emphasized in recent reviews. These pathways are crucial for various cellular processes ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Research on the development, physiology and pathophysiology of reproductive disorders is important, as evidence suggests that many adult-onset diseases can be traced back to disruptions during early ...

Delve into the increasingly dynamic landscape of ALS treatment development with thirteen companies advancing candidates in ...