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Scientists investigate a potential anti-aging drug that could preserve proteasomes and autophagy systems
The results were quite promising, as Prof. Hyun remarks, "Inhibiting the activity of ubiquitin specific peptidase 14 (USP14), a component of the proteasome complex, with IU1 enhanced not only ...
PNAS4y
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases
peptidase activity. Strikingly, we find the Machado–Joseph disease (MJD) class to be unappreciated non-lysine DUBs with highly specific ubiquitin esterase activity rivaling the efficiency of the most ...