Research has also delved into the mechanisms by which E3 ligases, such as Ark2C and UBR4, interact with E2 enzymes to facilitate ubiquitination. For instance, the structure of Ark2C has revealed ...

Here, we demonstrate that levels of F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase ... Mechanistically, FBXW7 binds to S6K1 and promotes its ubiquitination and ...

Motorola Moto E3 mobile was launched in July 2016. The phone comes with a 5.00-inch touchscreen display offering a resolution of 720x1280 pixels. Motorola Moto E3 is powered by a 1GHz quad-core ...

Center for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, DK-2100, Copenhagen, Denmark ...

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This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

This review outlines the relationships between substrate protein phosphorylation, acetylation, ubiquitination, SUMOylation, methylation, glycosylation, glycation, S-glutathionylation, S-nitrosylation ...

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Peerless Van der Poel triumphs over under-pressure Van Aert, though history shows nobody is unbeatable at Flanders and Roubaix ...

This useful study partially succeeds in providing solid evidence in support of the therapeutic potential of the plant-derived compound eugenol for ameliorating symptoms associated with STZ-induced ...