One major contributor to osteoporosis is estrogen deficiency, which is prevalent in postmenopausal women. Estrogen plays a vital role in maintaining bone density by inhibiting bone resorption and ...

Current therapies for the prevention and treatment of osteoporosis are limited by efficacy and patient compliance. RANKL/osteoprotegerin/RANK signaling regulates bone resorption and is essential ...

“Our findings suggest that injectable hydrogels with localized anti-catabolic drug delivery can complement systemic ...

Osteoporosis is a disabling skeletal disorder that is characterized by decreased bone strength, predisposing patients to increased risk of bone fracture. Peak bone mass (maximum bone strength and ...

Nat Clin Pract Endocrinol Metab. 2008;4(9):514-523. Whether patients with high bone-turnover rates will derive most benefit from treatments that reduce bone resorption and turnover (and vice ...

Osteoporosis, which affects approximately ... bone begins to weaken when bone resorption exceeds bone formation. Circulating osteoclast precursor cells exacerbate bone resorption and loss by ...

Osteoporosis is a disease in which bone resorbs faster than it is formed, gradually weakening its structure over time and ...

Objective: Osteoporosis is associated with an impaired balance between bone resorption and formation, which in turn leads to bone loss and fractures. Many recent studies have underlined the regulatory ...

Bone metastases are closely related to the biological activities of osteoblasts and osteoclasts, which are correlated with imbalanced activation of bone formation and bone resorption. As reported ...

By modulating both bone formation and resorption, iSN40 offers a potential new approach for the treatment of osteoporosis. Osteoporosis leads to reduced bone density and an increased risk of ...

One of only a handful of academic centers in the United States dedicated to skeletal health, the Johns Hopkins Metabolic Bone and Osteoporosis Center is committed to providing patients and their ...