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Cell:挑战传统感染模型——从HIV的“解体假说”到“完整穿越”
“完整穿越”模型的提出从根本上改变了我们对HIV感染过程的理解。传统假设认为,病毒通过解体将基因组暴露给宿主,这一过程是被动的、低效的。而新的研究揭示,病毒具有高度精确的“入侵策略”,包括巧妙利用衣壳结构与宿主核孔的相互作用,从而实现基因组的高效传递 ...
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