2023年8月16日 · High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However, whether PD-L1 expression in tumor cells is regulated by the availability of nutrients …

2022年9月6日 · Combined treatment with an HK inhibitor and an anti-PD-1 antibody eliminates tumor immune evasion and remarkably enhances the anti-tumor effect of immune checkpoint …

2024年8月23日 · Our research identified that the glycolysis-related gene (GRG) HK3 has a unique correlation with PD-L1 expression. HK3 has been identified as a key regulator of O …

2023年5月29日 · In this study, we demonstrated that aerobic glycolysis induces PD-L1 expression in an HK2-dependent manner. HK2 phosphorylates IκBα at T291, resulting in IκBα rapid …

2023年6月12日 · Under high glucose conditions, HK2 acts as a protein kinase and phosphorylates IκBα at T291 in breast cancer cells, leading to the rapid degradation of IκBα …

high glucose-induced PD-L1 expression and promoted CD8+ T cell activation and infiltration into the tumor tissue, reducing brain tumor growth. Combined treatment with an HK inhibitor and …

2025年1月23日 · Among all the catalytic enzymes participated in glycolysis, HK, PFK-1 and PK function as the rate-limiting enzymes [2, 17]. As PFK-1 characters the lowest catalyze activity, …

2023年6月12日 · 人类乳腺癌标本的免疫组织化学染色和生物信息学分析显示 HK2 和 PD-L1 表达水平之间呈正相关，与乳腺癌患者的免疫细胞浸润和生存时间呈负相关。 这些发现揭示了有 …

2022年9月28日 · 近日，欧洲科学院 Academia Europaea 外籍院士、浙江大学转化医学研究院/附属第一医院吕志民教授和团队研究了在高水平糖酵解条件下，肿瘤细胞 PD-L1 ...

2023年6月12日 · Immunohistochemistry staining of human breast cancer specimens and bioinformatics analyses reveals a positive correlation between HK2 and PD-L1 expression …