Light micrograph of an osteoclast displaying typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol. An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue.

2023年3月27日 · Osteoblasts and osteoclasts are special cells that help your bones grow and develop. Osteoblasts form new bones and add growth to existing bone tissue. Osteoclasts …

破骨细胞（Osteoclast，OC）是骨吸收的主要功能细胞，在骨发育、生长、修复、重建中具有重要的作用。 破骨细胞起源于血系单核－巨噬细胞系统，是一种特殊的终末分化细胞，它可由其单核前体细胞通过多种方式融合形成巨大的 多核细胞。 破骨细胞由多核巨细胞 (multi nuclear giant cell，MNGC)组成，直径100μm，含有2~50个紧密堆积的核，主要分布在骨质表面、骨内血管通道周围。 由多个单核细胞融合而成的，胞浆嗜碱性但随着细胞的老化，渐变为嗜酸性。 破骨细 …

2023年10月30日 · Osteoclasts are specialized bone matrix cells that possess the ability to erode bone, a process called resorption, during bone growth and remodeling. They are large, motile, …

2023年4月24日 · Functioning as vital cells in the bone matrix that maintains adequate bone mineral density through stimulating bone turnover and maintaining plasma calcium levels, osteoclasts are multinucleate cells that arise from hematopoietic stem cells.

Destruction, or resorption, of bone by large cells called osteoclasts releases calcium into the bloodstream to meet the body’s metabolic needs and simultaneously allows the bone—which is inhibited by its inorganic component from growing by cell division like other tissues—to alter size and shape as it grows to adult proportions.

Osteoclasts are highly specialized cells of haematopoietic lineage that are uniquely responsible for bone resorption. In the past, osteoclasts were isolated as mature cells from chicken long bones, or were generated using osteoblasts or stromal cells to induce osteoclast formation in total bone marrow from mice or rabbits.

Osteoclasts are multinucleated giant cells showing specialized membrane structures, clear zones and ruffled borders, which are responsible for the process of bone resorption. These cells arrive at the resorption site via the bloodstream as mononuclear cells, derived from haemopoietic precursors in t …

Osteoclasts are multinucleated giant cells that differentiate from myeloid precursors under the influence of the cytokines macrophage colony stimulating factor (MCSF) and receptor activator of NF-κB ligand (RANKL) supplied by osteoblasts and/or osteocytes (Figure 1A) [3].

Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.