Tetrahydrofuran-3,4-diol | C4H8O3 | CID 90803 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

四氢呋喃（thf），又名氧杂环戊烷、1,4-环氧丁烷，是一个杂环有机化合物，化学式为c 4 h 8 o，属于醚类，是呋喃的完全氢化产物。常温下为无色易挥发液体，有类似乙醚的气味。

2024年5月3日 · A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os (VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene ligated with citric acid and in the presence of Bro̷nsted acid.

2007年1月29日 · THF-diols and LTX-diols block female sexual behavior and cyclicity and stimulate breast cancer cell proliferation. Interestingly, the THF-diols, but not the LTX-diols, block male sexual behavior (Mani et al. 2005; Markaverich et al. 2005).

2008年6月18日 · Chromatin immunoprecipitation studies suggest THF-diols modify of histone H4 acetylation at the caveolin 1 promoter via an epigenetic mechanism. These findings are consistent with the well-known involvement of NOP genes in cell proliferation and sexual behavior.

A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os­(VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene ligated with citric acid and in the presence of Bro̷nsted acid.

2007年5月1日 · Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D- (+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

2024年5月4日 · A computational study is reported here on the mechanism of tetrahydrofuran (THF)-diol formation from the Os(VI)-catalyzed oxidative cyclization of 5,6-dihydroxyalkene ligated with citric acid and in the presence of Bro̷nsted acid.

Higher concentrations (1-2 ppm) of THF-diols were required to block male sexual behavior. Combination studies with subthreshold doses of 0.05 ppm THF-diols plus 0.05 ppm LTX-diols revealed that their effects on estrous cyclicity were not synergistic.

2007年6月1日 · THF-diols, LTX-diols, and/or their metabolites likely act additively to disrupt endocrine function in male and female rats at concentrations (0.5-1 ppm) that are 200-fold lower than those of...