2017年5月2日 · The cellular prion protein (PrP C) is a cell surface protein expressed in a variety of different organs and tissues with high expression levels in the central and peripheral …

The prion protein, PrP C, is a small, cell-surface glycoprotein notable primarily for its critical role in pathogenesis of the neurodegenerative disorders known as prion diseases.

The cellular form of the prion protein is involved in controlling cell cycle dynamics, self-renewal and the fate of human embryonic stem cell differentiation. J. Neurochem. 124, 310–322. doi: …

Here, we explore recent advances in prion disease research, from the func-tion of the cellular prion protein to the dysfunction triggering neurotoxicity, as well as mechanisms underlying …

2021年9月14日 · Prion protein has two isoforms including cellular prion protein (PrP C) and scrapie prion protein (PrP Sc). PrP Sc is the pathological aggregated form of prion protein and …

2020年9月25日 · Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in …

2017年11月18日 · The essential role of the cellular prion protein (PrPC) in prion disorders such as Creutzfeldt–Jakob disease is well documented. Moreover, evidence is accumulating that PrPC …

2017年8月31日 · The PrP can exist in 2 distinct conformations: the host-encoded, physiological cellular prion protein (PrP C) and the pathogenic isoform denoted as prion (usually referred to …

2020年11月5日 · The cellular prion protein (PrP C) is a cell surface glycophosphatidylinositol (GPI)-anchored protein consisting of 208 amino acids, and it is encoded by the PRNP gene …

2024年10月14日 · A prion is an infectious, misfolded protein that causes neurodegenerative diseases by inducing abnormal folding of normal cellular proteins, leading to the accumulation …