DNA Methylation and Its Basic Function
2012年7月11日 · In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5 …
A DNA methylation atlas of normal human cell types | Nature
2023年1月4日 · We identified more than one thousand cell-type-unique DNA methylation regions that could serve as accurate and specific biomarkers for fragment-level analysis and …
Fundamentals of DNA methylation in development
2024年12月10日 · DNA methyation is critical to regulation of gene expression especially during developmentally dynamic changes. A large proportion occurs at CpG (a cytosine followed by a …
A Practical Guide to the Measurement and Analysis of DNA Methylation
DNA methylation is a fundamental, dynamic epigenetic mark that is involved in myriad developmental, homeostatic, and pathologic processes. A detailed mechanistic understanding …
DNA Methylation Analysis: Choosing the Right Method - PMC
Careful interpretation of DNA methylation level should take into consideration the homogeneity of the cell population, as the resulting ratio is a snapshot of all DNA isolated from the sample. A …
DNA Methylation: Genomewide Distribution, Regulatory …
DNA methylation is the most important epigenetic modification involved in the regulation of transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin …
Guidance for DNA methylation studies: statistical insights from …
2019年5月14日 · We quantified DNA methylation in the Understanding Society cohort (n = 1175), a large population based study, using the Illumina EPIC array to assess the statistical …
Estimating genome-wide DNA methylation heterogeneity with methylation …
2023年11月9日 · We adopted the mathematical framework from biodiversity into three model-based methods for analyzing genome-wide DNA methylation heterogeneity to monitor cellular …
DNA methylation methods: Global DNA methylation and methylomic ... - PubMed
In this review, we discuss the different DNA methylation analysis technologies primarily based on the initial treatments of DNA samples: bisulfite conversion, endonuclease digestion and affinity …
Genetic impacts on DNA methylation: research findings and future ...
2021年4月30日 · Multiple recent studies highlight that genetic variants can have strong impacts on a significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …