Intestinal SGLT1 in metabolic health and disease - PubMed
2016年6月1日 · Intestinal SGLT1 inhibition lowers and delays the glucose excursion following CHO ingestion and augments glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretion. The latter is likely due to increased glucose exposure of the colonic microbiota and formation of metabolites such as L cell secretagogues.
Structure and mechanism of the SGLT family of glucose transporters
SGLT1, the first cloned transporter within the large sodium-solute symporter (SSS) family 2, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling stoichiometry 2, 6. SGLT1 mediates active glucose and galactose absorption in the intestine as well as renal glucose scavenging 4.
The role of SGLT1 and GLUT2 in intestinal glucose transport ... - PubMed
2014年2月26日 · Intestinal glucose absorption is mediated by SGLT1 whereas GLUT2 is considered to provide basolateral exit. Recently, it was proposed that GLUT2 can be recruited into the apical membrane after a high luminal glucose bolus allowing bulk absorption of glucose by facilitated diffusion.
Glucose transporters in the small intestine in health and disease
Ruminant sheep exhibit an extensive, carbohydrate-dependent regulation of SGLT1. In the small intestine of lambs, SGLT1 is highly expressed during breastfeeding when d-glucose and d-galactose enter the small intestine whereas SGLT1 expression is largely reduced after weaning when the rumen where carbohydrates are fermented has maturated and no ...
Intestinal SGLT1 in metabolic health and disease
2016年6月1日 · Intestinal SGLT1 inhibition lowers and delays the glucose excursion following CHO ingestion and augments glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretion. The latter is likely due to increased glucose exposure of the colonic microbiota and formation of metabolites such as L cell secretagogues.
The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and …
2014年2月26日 · SGLT1 is unequivocally the prime intestinal glucose transporter even at high luminal glucose concentrations. Moreover, SGLT1 mediates glucose-induced incretin secretion. Our studies do not provide evidence for GLUT2 playing any role in either apical glucose influx or incretin secretion.
Glucose transporters in the small intestine in health and disease
The review describes functions and regulations of SGLT1, GLUT2, and GLUT5 in the small intestine including diurnal variations and carbohydrate-dependent regulations. Also, the roles of SGLT1 and GLUT2 for secretion of enterohormones are discussed.
Sodium/glucose cotransporter 1 - Wikipedia
Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene [4] [5] which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. [6]
Rapid Upregulation of Sodium-Glucose Transporter SGLT1 in Response …
We set out to examine the short-term regulation of the intestinal sodium/glucose cotransporter SGLT1 by its substrate glucose and sweet taste analogs. Intestinal SGLT1 is a putative target for antidiabetic therapy; however, its physiological regulation is incompletely understood, limiting its application as a pharmacological target.
Structure and mechanism of the SGLT family of glucose …
2021年12月8日 · SGLT1, the first member of the large sodium–solute symporter (SSS) family 2 to be identified, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling...