2006年9月22日 · Early signaling in camptothecin-treated MCF-7 cells followed an intrinsic pathway, but death was delayed and late events exhibited few hallmarks of apoptosis. BH3-only proteins, such as Noxa,...

2021年8月1日 · We first examined the ability of various PUFAs to modulate the expression of autophagy-related proteins in MCF-7 cells. In this study, results indicate that increase in LC3-Π/-I ratio and SQSTM1 expression as well as decrease in mTOR expression is greater in DHA-treated cells compared with those treated with other PUFAs ( Fig. 1 A).

In this study, we propose that TPI induces MCF-7 cell apoptosis through the mitochondrial pathway, the mTOR/Erk/p38 MAPK signaling pathway and autophagy. We have shown that Erk activation is associated with autophagy induction and apoptosis; U0126 reversed the mediating effect of TPI on protein expression, indicating that the regulation of Erk ...

ApoG2 has been demonstrated to have superior anti-tumor activity than gossypol in Bcl-2 transgenic mice. The purpose of this study was to investigate the inhibitory effect of ApoG2 on breast cancer cell line MCF-7 in vitro and in vivo, and to investigate its anti-tumor mechanism. Methods: MCF-7 cell line in culture was treated with ApoG2. The ...

2015年3月19日 · Our results show that increasing ZNF32 expression in MCF-7 cells inhibits autophagy initiation by activating the AKT/mTOR pathway, and further reduced autophagy-associated cell death and maintained MCF-7 cell survival.

We demonstrate that, in MCF7 cells, the combination of either miR-34a or miR-34c mimic with AdoMet greatly potentiated the pro-apoptotic effect of AdoMet, by a caspase-dependent mechanism and activates p53 acetylation by inhibiting SIRT1 and HDAC1 expression.

2018年11月19日 · In this study, we determined an upregulation of autophagy by Rg2. Rg2 treatment for 24 h in MCF-7, a breast cancer cell, did not show cytotoxicity up to 200 μM. Rg2 also upregulated the level of p-p53, p-AMPK, p-ACC, Atg-7 and LC3-II and decreased the level of p62 in concentration-dependent manners.

2022年5月25日 · We also explored the potential mechanism of the enhanced effect of UA on the sensitivity of MCF-7 and MDA-MB-231 cells to EPI. Our results illustrated UA had effects on the class III PI3K(VPS34)/Beclin-1 pathway and PI3K/AKT/mTOR pathway to enhance the EPI-induced autophagy in MCF-7 and MDA-MB-231 cells.

This study aimed to determine the apoptosis and autophagy-inducing mechanism of atractylodin in human breast cancer MCF-7 cells. The molecular mechanism of anticancer activity of atractylodin was confirmed by assessing the levels of reactive oxygen species (ROS) level, lipid peroxidation (LPO), anti …

2019年3月1日 · Autophagy* Glycolysis* Humans Intracellular Signaling Peptides and Proteins / physiology* MCF-7 Cells