Roles of macrophages in tumor development: a spatiotemporal
2023年7月10日 · Tumor-associated macrophages favor tumor development through different functions. TAMs have various roles in tumorigenesis and as such, interact closely with cancer cells and the TME.
The Role of Macrophages in Cancer Development and Therapy
Tumor-Associated Macrophages (TAMs) play an important role in the development of tumors, modulation of neoangiogenesis, immune suppression, and metastasis. High infiltration of macrophages in the tumor is also correlated with poor prognosis in ...
Macrophages as tools and targets in cancer therapy
2022年8月16日 · Macrophages have the potential to kill tumour cells, mediate antibody-dependent cellular cytotoxicity and phagocytosis, elicit vascular damage and tumour necrosis 4, and activate...
The complex role of tumor-infiltrating macrophages - Nature
2022年7月25日 · Tumor-associated macrophages (TAMs) represent the most abundant innate immune population in the tumor microenvironment (TME). Macrophages are professional phagocytic cells of the...
Roles of macrophages in tumor development: a spatiotemporal …
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support tumor development.
New insights into M1/M2 macrophages: key modulators in cancer ...
In this review, mechanisms underlying the distinct functional characterization of M1 and M2 macrophages are demonstrated to make sense of M1 and M2 as key regulators during cancer progression. Keywords: Tumor-associated macrophages, Cancer, Metastasis, Polarization.
The Role of Macrophages in Various Types of Tumors and the
6 天之前 · In solid tumors, tumor-associated macrophages (TAMs) are one of the most numerous populations and play an important role in the processes of tumor cell invasion, metastasis, and angiogenesis. Therefore, TAMs are considered promising diagnostic and prognostic biomarkers of tumors, and many attempts have been made to influence these cells as part of antitumor therapy.
The crosstalk between macrophages and cancer cells potentiates ...
2024年5月13日 · Herein, we investigate the critical role of macrophages in potentiating pancreatic cancer induced muscle wasting via promoting TWEAK (TNF-like weak inducer of apoptosis) secretion from the tumor. Specifically, depletion of macrophages reverses muscle degradation induced by tumor cells.
A temporal perspective for tumor-associated macrophage …
By instilling temporal dynamism into the more static classic view of tumor-associated macrophage biology, we propose a new framework to better contextualize their significance in the inflammatory processes that precede and result from the onset of cancer and shape its evolution.
Tumor macrophage functional heterogeneity can inform the …
Single cell transcriptomics and spatial profiling have revealed that tumor-associated macrophages comprise multiple subtypes (molecularly), and harbor different functions within the tumor microenvironment. This can depend on their spatial localization, tumor type, and disease stage.
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