The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. [5] Calcitriol (the active form of vitamin D, 1,25-(OH) 2 vitamin D 3) binds to VDR, which then forms a heterodimer with the retinoid-X receptor.

Vitamin D receptor (VDR) is a member of the nuclear receptor superfamily. 1α,25-Dihydroxyvitamin D3 [1α,25 (OH) 2 D 3] is an active form of secosteroid hormone vitamin D 3 and acts as a ligand-dependent transcriptional regulator in the genomic pathway, which involves binding of ligand to VDR, formation of a heterodimer complex with retinoid X re...

The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca 2+ levels that serve to regulate several biological functions. However, the roles of vitamin D and its metabolism in maintaining gastric homeostasis have not yet been completely elucidated.

2012年7月1日 · The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, lar …

The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH) 2 D 3, regulates the expression of more than 900 genes involved in a wide array of physiological functions.

In this review, we present different perspectives on the VDR that incorporate its role as transcription factor and member of the nuclear receptor superfamily, its dynamic changes in genome-wide locations and DNA binding modes, its interaction with chromatin components and its primary protein-coding and non-protein coding target genes and finally...

The vitamin D receptor (VDR) is an endocrine member of the nuclear receptor superfamily for steroid hormones and binds the biologically most active vitamin D metabolite, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) (10).

The VDR gene provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond to vitamin D. This vitamin can be acquired from foods in the diet or made in the body with help from sunlight exposure.

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene.

Classically, vitamin D is known to regulate skeletal and mineral ion homeostasis. The active form of vitamin D, 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3], binds with high affinity to the vitamin D receptor (VDR) to perform vitamin D’s biological